Selphyl® Platelet-Rich Fibrin Matrix System

• Superior Technology.
• Visual Guide to Quality.
• Completely Closed System.
• Ultrapure PRFM.
• Sustained GF Release.
• Extensive Safety Profile.
• Over 150K Patients Treated.

WHAT IS PLATELET-RICH PLASMA (PRP)?
PRP, by definition, refers to platelets in plasma, where the platelet concentration is generally considered to be twice the normal concentration in whole blood. Nowhere in the definition of PRP is there a description for including red blood cells (RBC) or white blood cells (WBC) – in fact, these cells should be removed as much as possible from a PRP preparation. Some kits that tout high platelet concentrations often do so at the expense of having contaminating RBCs or WBCs – these cells are known to have inflammatory and catabolic effects – just the opposite of the desired effect. If the PRP in the syringe has any tinge of pink or red, it is most likely that you are injecting a preparation that has RBC contamination. The ideal PRP solution will be a golden, straw-like color.

WHAT IS SELPHYL® PRFM?
The Selphyl® System is designed for the safe and rapid preparation of Platelet-rich Fibrin Matrix (PRFM) from a small sample of blood at the patient's point of care. Many PRP systems require operator skills, have varying results, and have extensive contamination with red blood cells and white blood cells. Selphyl® removes virtually all contaminating cells and is independent of the operator technique. PRP is converted to PRFM through a controlled process, creating a scaffold that serves to protect and preserve platelets. Think of Selphyl® PRFM as the next generation PRP.

HOW IS SELPHYL® PLATELET-RICH FIBRIN MATRIX (PRFM) DIFFERENT?
The Selphyl® System is a completely closed system and can convert PRP to PRFM with the addition of a precise amount of calcium chloride, which initiates the conversion of fibrinogen to fibrin, as part of the clotting cascade. The fibrin matrix serves as a three-dimensional scaffold to maintain the platelets at the site of injection. The scaffold also serves to protect the platelets so their release of growth factors can be sustained over a longer period of time.

HOW LONG DOES THE PROCEDURE TAKE?
The entire procedure takes about 30 minutes to perform in your doctor’s office.

HOW MANY TREATMENTS ARE NEEDED?
The number of treatments needed depends on each individual patient, the desired outcome, and your doctor’s treatment plan.

IS THE TREATMENT PAINFUL?
Unlike other products that are acidic (low pH), Selphyl® PRFM has close to physiologic pH. There may be some temporary discomfort during the injections. Like all injection procedures, one can experience occasional redness and bruise immediately following the treatment that resolves quickly.

ARE THERE ANY SIDE EFFECTS?
There have been no known side effects associated with Selphyl® reported to date. As with any injectable procedure, some patients may experience some mild and temporary irritation, swelling, bruising, itching, discoloration, or tenderness at the injection site.

CAN ANYONE BE ALLERGIC TO SELPHYL®?
There is virtually no risk of allergic reaction. The Selphyl® PRFM System is used to rapidly collect and isolate a patient’s own PRFM for injection and contains no animal or synthetic products.